NGS-SA: Publications and pre-prints of our genomics surveillance work

Unlocking the efficiency of genomics laboratories with robotic liquid-handling

Authors: Tegally H, San JE, Giandhari J, de Oliveira T

Journal: BMC Genomics, 2020. DOI:


In research and clinical genomics laboratories today, sample preparation is the bottleneck of experiments, particularly when it comes to high-throughput next generation sequencing (NGS). More genomics laboratories are now considering liquid-handling automation to make the sequencing workflow more efficient and cost effective. The question remains as to its suitability and return on investment. A number of points need to be carefully considered before introducing robots into biological laboratories. Here, we describe the state-of-the-art technology of both sophisticated and do-it-yourself (DIY) robotic liquid-handlers and provide a practical review of the motivation, implications and requirements of laboratory automation for genome sequencing experiments.